From clinical trials to in-silico trials: virtual twins, virtual chimeras, and not a patient in sight
(Associate Professor School of Mechanical Engineering)
New medical devices must successfully pass through clinical trials before they can be certified for use. These trials are very expensive and lengthy, and necessarily limited in scope. Some advocate a new approach, called in-silico trials, in which we create cohorts of virtual patients, virtually implant a digital replica of the device in each, and predict its performance at any point from then on. In this talk, I will briefly describe how in-silico trials can be realised in practice, summarise their potential benefits, and touch on their limitations and the gaps that still need to be filled.