Professor Alex Frangi is Diamond Jubilee Chair in Computational Medicine and Royal Academy of Engineering Chair in Emerging Technologies at the University of Leeds, Leeds, UK, with joint appointments at the School of Computing and the School of Medicine. He directs the CISTIB Center for Computational Imaging and Simulation Technologies in Biomedicine. In this episode, we discuss computational medicine, the promises of in-silico trials and his new paper In-silico trial of intracranial flow diverters replicates and expands insights from conventional clinical trials.