Professor Alejandro Frangi, of CISTIB at the University of Sheffield and co-investigators at the University of Manchester and University of Cardiff with collaborators at the University of Antwerp and CEA-NeuroSpin along with industrial partners and charities in the UK and Europe have been awarded £1.3 million from EPSRC to characterise and quantify early differential alterations in brain blood transport and subsequent microstructural tissue damage with a novel MRI technique. 

The project, entitled One-stop-shop microstructure-sensitive perfusion/diffusion MRI: Application to vascular cognitive impairment, will deliver MRI sequences and analysis tools to link neuropathology, neuroimaging, and biophysics, thus being optimally positioned to discover novel biomarkers of disease onset and progression, and to understand the effects of novel drugs and treatments.

The 3 year project, was ranked 1st out of 5 proposals funded from 40 submissions and involves the University’s Faculty of Engineering (CISTIB and INSIGNEO), Faculty of Medicine, Dentistry and Health (SITraN and INSIGNEO) and Department of Psychology (Pre-Clinical MRI Facility), as well as charities and industrial partners from the UK and Europe.

Prof Frangi said “we are delighted by this phenomenal opportunity to contribute to the efforts to combat dementias. It is through interdisciplinary efforts like OCEAN that we will be able to develop appropriate diagnostic and staging tools for the disease. I am really proud to count for this journey with colleagues in SITraN and INSIGNEO as well as with experts in Manchester and Cardiff, and beyond.”

http://gow.epsrc.ac.uk/NGBOViewGrant.aspx?GrantRef=EP/M006328/1

Site URL: http://www.ocean-mri.org/ 

Investigators

Name	Role	Institution
Frangi, Professor AF	Principal Investigator
Kennerley, Dr AJ	Co-Investigator
Parker, Professor G	Co-Investigator
Venneri, Professor A	Co-Investigator
Highley, Dr R	Co-Investigator
Jones, Professor DK	Co-Investigator
Taylor, Dr ZA	Co-Investigator
Wilkinson, Professor ID	Co-Investigator
Ince, Professor PG	Co-Investigator
Dr L Beltrachini	Researcher Co-Investigator

 

Project Partners

INSTITUTIONS
Academic Institutions
Collaborating institutions

 

COLLABORATORS
Industrial Partners
Networks & Platforms