WP Leader: Prof. Yiannis Ventikos, University College London, UK
Central to the integrative treatment of the brain as an organ of very high metabolic demand, is the development and expansion of a modelling platform that can handle, in an anatomically accurate, patient specific manner, the transport and interplay of blood and cerebrospinal fluid with the parenchyma – the neuronal and astrocyte tissue that constitutes the functioning brain.
The focus of this work package is to lead and contribute to the development of a simulation platform capable of representing, for the first time, the transport processes in the cerebral environment in their entirety and in a coupled manner. This involves the expansion of an existing proven conceptual framework – that of multicompartmental poroelasticity. It accounts for anatomically derived, healthy and diseased, cases that are utilised for equipping VPH-DARE@IT with realistic, experimentally-derived, micro-laws of transport, absorption and regulation in the cerebral environment.