WP Leader:  Prof. Yiannis Ventikos, University College London, UK

Multiscale multifactorial multiparadigm modelling

Central to the integrative treatment of the brain as an organ of very high metabolic demand, is the development and expansion of a modelling platform that can handle, in an anatomically accurate, patient specific manner, the transport and interplay of blood and cerebrospinal fluid with the parenchyma – the neuronal and astrocyte tissue that constitutes the functioning brain.

The focus of this work package is to lead and contribute to the development of a simulation platform capable of representing, for the first time, the transport processes in the cerebral environment in their entirety and in a coupled manner.  This involves the expansion of an existing proven conceptual framework – that of multicompartmental poroelasticity. It accounts for anatomically derived, healthy and diseased, cases that are utilised for equipping VPH-DARE@IT with realistic, experimentally-derived, micro-laws of transport, absorption and regulation in the cerebral environment.

Work Packages

  • Work Package 1

    Clinical Study Design. Clinical Verification of Models and Platforms
    WP Leader: Dr. Hilkka Soininen, University of Eastern Finland
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  • Work Package 2

    Novel imaging disease biomarkers & methods for model personalization
    WP Leader: Dr. Zeike Taylor, University of Sheffield
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  • Work Package 3

    Data Access & Disease Biomarkers from Large-scale Population Studies
    WP Leader: Prof. Sabastien Ourselin, University College London
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  • Work Package 4

    Genetic, Biochemical and Metabolic Pathways Modelling with Environmental Influence
    WP Leader: Dr. Catrin Bludszuweit-Philipp, ASD, Germany
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  • Work Package 5

    Multiscale Biophysical & Biochemical Modeling: Brai n Substrate and its Evolution
    WP Leader: Prof. Yiannis Ventikos, University College London, UK
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  • Work Package 6

    Multiscale Phenomenological Modelling: Clinical & Environment Factors
    WP Leader: Prof. Wiro Neissen, Erasmus MC, The Netherlands
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  • Work Package 7

    Biomedical Research Platform for Disease Modelling and Model Personalisation
    WP Leader: Dr. Alberto Biancardi, University of Sheffield, UK
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  • Work Package8

    Decision Support Platform for Early Differential Diagnosis & Disease Evolution Assessment
    WP Leader: Dr. Jyrki Lötjönen, VTT, Finland
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  • Work Package 9

    Technology Assessment, Market Analysis and Exploitation
    WP Leader: Dr. Rainer Thiel, Empirica, Germany
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  • Work Package 10

    Technical Management, Communication and Outreach
    WP Leader: Mr. Juan Arenas, University of Sheffield, UK
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