WP Leader:  Dr. Catrin Bludszuweit-Philipp, ASD, Germany

wp4The first goal of this work package is the development of a consistent knowledge base about dementia-related metabolites in the brain and their interdependencies.  Hereafter, a sound modelling platform will be built that can organise the vast amount of input data concerning patient-specific brain metabolism and genetic/environmental/lifestyle data.

This work package aims at the development and integration of genetic, biochemical and metabolic pathway modelling approaches that will allow for the identification of pathways leading to the neurodegenerative disease and will enable the user to investigate effects following the alteration of certain model components, i.e. by medication or through life style changes.

This knowledge will be converted into computational models to build a clinically applicable method of disease assessment and differential diagnosis.

Work Packages

  • Work Package 1

    Clinical Study Design. Clinical Verification of Models and Platforms
    WP Leader: Dr. Hilkka Soininen, University of Eastern Finland
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  • Work Package 2

    Novel imaging disease biomarkers & methods for model personalization
    WP Leader: Dr. Zeike Taylor, University of Sheffield
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  • Work Package 3

    Data Access & Disease Biomarkers from Large-scale Population Studies
    WP Leader: Prof. Sabastien Ourselin, University College London
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  • Work Package 4

    Genetic, Biochemical and Metabolic Pathways Modelling with Environmental Influence
    WP Leader: Dr. Catrin Bludszuweit-Philipp, ASD, Germany
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  • Work Package 5

    Multiscale Biophysical & Biochemical Modeling: Brai n Substrate and its Evolution
    WP Leader: Prof. Yiannis Ventikos, University College London, UK
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  • Work Package 6

    Multiscale Phenomenological Modelling: Clinical & Environment Factors
    WP Leader: Prof. Wiro Neissen, Erasmus MC, The Netherlands
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  • Work Package 7

    Biomedical Research Platform for Disease Modelling and Model Personalisation
    WP Leader: Dr. Alberto Biancardi, University of Sheffield, UK
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  • Work Package8

    Decision Support Platform for Early Differential Diagnosis & Disease Evolution Assessment
    WP Leader: Dr. Jyrki Lötjönen, VTT, Finland
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  • Work Package 9

    Technology Assessment, Market Analysis and Exploitation
    WP Leader: Dr. Rainer Thiel, Empirica, Germany
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  • Work Package 10

    Technical Management, Communication and Outreach
    WP Leader: Mr. Juan Arenas, University of Sheffield, UK
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