WP Leader: Dr. Catrin Bludszuweit-Philipp, ASD, Germany
The first goal of this work package is the development of a consistent knowledge base about dementia-related metabolites in the brain and their interdependencies. Hereafter, a sound modelling platform will be built that can organise the vast amount of input data concerning patient-specific brain metabolism and genetic/environmental/lifestyle data.
This work package aims at the development and integration of genetic, biochemical and metabolic pathway modelling approaches that will allow for the identification of pathways leading to the neurodegenerative disease and will enable the user to investigate effects following the alteration of certain model components, i.e. by medication or through life style changes.
This knowledge will be converted into computational models to build a clinically applicable method of disease assessment and differential diagnosis.