WP Leader:  Prof. Sabastien Ourselin, University College London

brainNumerous studies in Alzheimer’s disease and related dementias have been performed in order to identify the most promising biomarkers for early detection of the disease, monitoring disease progression, and measuring the effectiveness of potential treatments during clinical trials. These initiatives have collected substantial amounts of imaging, cognitive, fluid, lifestyle, and genetic data on the healthy ageing, those who have memory problems and likely to develop dementia, and patients affected by Alzheimer’s and other dementias.

This work package, combines all of this information and extracts relevant image-based biomarkers using existing, well-validated tools in order to provide the most comprehensive set of data on the disease process.

This data will then serve as inputs for the models that will be constructed in other work packages.

Work Packages

  • Work Package 1

    Clinical Study Design. Clinical Verification of Models and Platforms
    WP Leader: Dr. Hilkka Soininen, University of Eastern Finland
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  • Work Package 2

    Novel imaging disease biomarkers & methods for model personalization
    WP Leader: Dr. Zeike Taylor, University of Sheffield
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  • Work Package 3

    Data Access & Disease Biomarkers from Large-scale Population Studies
    WP Leader: Prof. Sabastien Ourselin, University College London
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  • Work Package 4

    Genetic, Biochemical and Metabolic Pathways Modelling with Environmental Influence
    WP Leader: Dr. Catrin Bludszuweit-Philipp, ASD, Germany
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  • Work Package 5

    Multiscale Biophysical & Biochemical Modeling: Brai n Substrate and its Evolution
    WP Leader: Prof. Yiannis Ventikos, University College London, UK
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  • Work Package 6

    Multiscale Phenomenological Modelling: Clinical & Environment Factors
    WP Leader: Prof. Wiro Neissen, Erasmus MC, The Netherlands
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  • Work Package 7

    Biomedical Research Platform for Disease Modelling and Model Personalisation
    WP Leader: Dr. Alberto Biancardi, University of Sheffield, UK
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  • Work Package8

    Decision Support Platform for Early Differential Diagnosis & Disease Evolution Assessment
    WP Leader: Dr. Jyrki Lötjönen, VTT, Finland
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  • Work Package 9

    Technology Assessment, Market Analysis and Exploitation
    WP Leader: Dr. Rainer Thiel, Empirica, Germany
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  • Work Package 10

    Technical Management, Communication and Outreach
    WP Leader: Mr. Juan Arenas, University of Sheffield, UK
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