This project is a consortium of highly recognised engineering, physical, biomedical and clinical scientists and industrial partners from across Europe.

We will deliver the first patient-specific predictive models for early differential diagnosis of dementias and their evolution.

An integrated clinical decision-support platform will be tested by access to a dozen databases of international studies.

This will be first integrative and validated multiscale modelling platform for biomedical research and clinical decision support.

To do this, the project is broken down into a number of work packages. Each work package (WP) is a subset of the project that executes a specific part of the project.

There are 10 workpackages in VPH-DARE@IT, each contributing to the overall aim of: providing a systematic, multifactorial and multiscale modelling approach to understanding dementia onset and progression and enable more objective, earlier, predictive and individualised of the disease.

Work Packages

  • Work Package 1

    Clinical Study Design. Clinical Verification of Models and Platforms
    WP Leader: Dr. Hilkka Soininen, University of Eastern Finland
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  • Work Package 2

    Novel imaging disease biomarkers & methods for model personalization
    WP Leader: Dr. Zeike Taylor, University of Sheffield
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  • Work Package 3

    Data Access & Disease Biomarkers from Large-scale Population Studies
    WP Leader: Prof. Sabastien Ourselin, University College London
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  • Work Package 4

    Genetic, Biochemical and Metabolic Pathways Modelling with Environmental Influence
    WP Leader: Dr. Catrin Bludszuweit-Philipp, ASD, Germany
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  • Work Package 5

    Multiscale Biophysical & Biochemical Modeling: Brai n Substrate and its Evolution
    WP Leader: Prof. Yiannis Ventikos, University College London, UK
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  • Work Package 6

    Multiscale Phenomenological Modelling: Clinical & Environment Factors
    WP Leader: Prof. Wiro Neissen, Erasmus MC, The Netherlands
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  • Work Package 7

    Biomedical Research Platform for Disease Modelling and Model Personalisation
    WP Leader: Dr. Alberto Biancardi, University of Sheffield, UK
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  • Work Package8

    Decision Support Platform for Early Differential Diagnosis & Disease Evolution Assessment
    WP Leader: Dr. Jyrki Lötjönen, VTT, Finland
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  • Work Package 9

    Technology Assessment, Market Analysis and Exploitation
    WP Leader: Dr. Rainer Thiel, Empirica, Germany
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  • Work Package 10

    Technical Management, Communication and Outreach
    WP Leader: Mr. Juan Arenas, University of Sheffield, UK
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What is VPH-DARE@IT?

“Virtual Physiological Human: DementiA Research Enabled by IT” Read More
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What is Dementia?

"This syndrome has adverse effects in the quality of life of tens of millions of people" Read More
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Who is affected?

"Approximately 35 million worldwide people suffer from dementia." Read More
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How to address this?

"There are 10 workpackages contributing to the overall aims of the project." Read More
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What is the expected impact?

"The project will improve the health care of dementia patients." Read More
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