A European collaborative project focused on dementia.

    Project funded by the European Commission

    Project funded by the European Commission

    Early diagnosis

    This project will deliver more objective and accurate differential diagnosis than what is available thus far in Europe,
  • Risk Factors

    We are exploring the lifestyle and environmental factors that predispose the development of Dementia
  • Accurate differential diagnosis

    The final objective is to turn know-how and methods into an innovative, integrative and objective clinical decision support platform for the early and differential diagnosis of memory disorders.
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What is VPH-DARE@IT?

“Virtual Physiological Human: DementiA Research Enabled by IT” Read More

What is Dementia?

"This syndrome has adverse effects in the quality of life of tens of millions of people" Read More

Who is affected?

"Approximately 35 million worldwide people suffer from dementia." Read More

How to address this?

"There are 10 workpackages contributing to the overall aims of the project." Read More

What is the expected impact?

"The project will improve the health care of dementia patients." Read More
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  • What is the expected impact of VPH-DARE@IT?

    The expected impact of the project will influence the scientific, clinical and industrial communities across Europe and internationally to improve the healthcare of dementia patients.

    This will both improve patients’ quality of life, and also reduce the burden on carers and the costs of supporting people with dementia.
  • Expected Results & Impact

    VPH-DARE@IT’s aim is to enable more objective, earlier, predictive and individualised diagnoses and prognoses of dementias to cope with the challenge of an ageing European society. This aim includes the following results:

    • Novel biomedical dementia biomarkers 
    • Personalised, multi-factorial brain models, taking into account genetics, metabolism, biophysics, physiology and environmental influences
    • Advanced brain image analysis tools
    • An integrative and personalised modelling platform to support clinical research in dementia
    • A clinical platform for personalised diagnosis of dementia and assessment of treatment efficacy
    • A framework for sharing & combining data from large databases
  • Impact

    The impact of VPH-DARE@IT listed below are expected to range across the scientific, clinical and industrial communities across Europe and abroad, to improve health care of dementia patients:

    • Provide earlier personalised prognoses and diagnoses and treatment onset, meaning reduced suffering for the individual and their relatives.
    • Integrate lifestyle and other environmental factors and data with clinical, biological, and physiological factors and determine their impact on disease progression and prevention.
    • Ensure greater equality between citizens through systematic and objective diagnoses. Quality of healthcare currently depends on where someone is living and the capacities of their local hospital.
    • Estimate healthcare cost reduction based on published models of state-of-the-art treatment action. Real cost reduction will require, in addition to earlier diagnosis, an estimate of the delay in the progress of dementia achievable with future treatments.
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More About VPH-DARE@IT

How we will address this

This project is a consortium of highly recognised engineering, physical, biomedical and clinical scientists and industrial partners from across Europe.
We will deliver the first patient-specific predictive models for early differential diagnosis of dementias and their evolution.
An integrated clinical decision-support platform will be tested by access to a dozen databases of international studies.
This will be first integrative and validated multiscale modelling platform for biomedical research and clinical decision support.
To do this, the project is broken down into a number of work packages. Each work package (WP) is a subset of the project that executes a specific part of the project.
There are 10 workpackages in VPH-DARE@IT, each contributing to the overall aim of: providing a systematic, multifactorial and multiscale modelling approach to understanding dementia onset and progression and enable more objective, earlier, predictive and individualised of the disease.

Read more


Work Packages

  • Work Package 1

    Clinical Study Design. Clinical Verification of Models and Platforms
    WP Leader: Dr. Hilkka Soininen, University of Eastern Finland
    Read More
  • Work Package 2

    Novel imaging disease biomarkers & methods for model personalization
    WP Leader: Dr. Zeike Taylor, University of Sheffield
    Read More
  • Work Package 3

    Data Access & Disease Biomarkers from Large-scale Population Studies
    WP Leader: Prof. Sabastien Ourselin, University College London
    Read More
  • Work Package 4

    Genetic, Biochemical and Metabolic Pathways Modelling with Environmental Influence
    WP Leader: Dr. Catrin Bludszuweit-Philipp, ASD, Germany
    Read More
  • Work Package 5

    Multiscale Biophysical & Biochemical Modeling: Brain Substrate and its Evolution
    WP Leader: Prof. Yiannis Ventikos, University College London, UK
    Read More
  • Work Package 6

    Multiscale Phenomenological Modelling: Clinical & Environment Factors
    WP Leader: Prof. Wiro Neissen, Erasmus MC, The Netherlands
    Read More
  • Work Package 7

    Biomedical Research Platform for Disease Modelling and Model Personalisation
    WP Leader: Dr. Alberto Biancardi, University of Sheffield, UK
    Read More
  • Work Package8

    Decision Support Platform for Early Differential Diagnosis & Disease Evolution Assessment
    WP Leader: Dr. Jyrki Lötjönen, VTT, Finland
    Read More
  • Work Package 9

    Technology Assessment, Market Analysis and Exploitation
    WP Leader: Dr. Rainer Thiel, Empirica, Germany
    Read More
  • Work Package 10

    Technical Management, Communication and Outreach
    WP Leader: Mr. Juan Arenas, University of Sheffield, UK
    Read More
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Keep up to date with project news via our bi-annual newsletter

Issue II

September 2014

Issue I

February 2014
  • Project News +

    Check out what we have been up to, events we will be at and the latest project news. Read More
  • Publications +

    Learn more about the ongoing research in VPH-DARE@IT Read More
  • Deliverables +

    Further detail on the project, and output to date. Read More
  • Learn More +

    Links to further information and support. Read More
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Information for patients and the public

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